The current volume of the yearbook shows current trends and future horizons of research into the history of universities and science. These include the recently established, culturally and historically broad perspective of the history of knowledge, which opens up new approaches to the historiographical tradition, as well as the use of digital methods for the historical sciences and the public reception of their research findings (digital humanities, public history). Studies on persecuted Jewish academics during the National Socialist era continue to be of particular current relevance. The thematic focus offers a classic topic in a new methodological format, with contributions examining the upheaval at universities around and after 1500: In the field of tension between ecclesiastical tradition, scholarly innovation and the new beginnings of the Reformation, the significance and impact of humanism are presented, particularly using the University of Erfurt as an example.